The book objective is to explore environment caused changes on internal characteristics of an organic molecule. Hydrogen network of polar solvent molecules and zero point energy have to be taken into consideration for the correct qualitative, quantitative interpretation of intermolecular proton transfer pathways. Anil-type molecules conformational variability in polar solvents is competing with solvent molecules clusters formation. Bacteriorhodopsin dipole moment is defined by cytoplasmic and extracellular coils of the membrane. Cyanine class molecule experiences deformations in solvent...