The brain disorders are very challenging to treat in efficient way. The common CNS disorders like epilepsy yet is poorly treated disease. The CNS disorder treatment is not efficient as compared to other diseased area therapy. The great hurdle in designing the brain targeted drug delivery system is blood brain barrier. So as per the advancement of researches one of the strategy by developing the different formulations has been used. In this review article the research work on novel approach for targeting the drug to brain by administering through the ear route. But now days as per the...