This monograph introduces the excellent application of olefin metathesis approah for total synthesis biologically potent 10-membered lactone derived natural products, such as (+)-Mueggelone (a novel inhibitor of fish development), Herbarumin-I (Which interacts with bovine-brain calmodulin and inhibited the activation of the calmodulin-dependent enzyme cAMP phosphodiesterase and should have physiological effects of agrochemical and medicinal interest), and Stagonolides (which were shown to be a nonhost-speci c but selective phytotoxin. Leaves of C. arvense were most sensitive and leaves of...