Abstract: Schistosomiasis remains one of the most prevalent parasitic diseases in the sub-Saharan Africa including Ethiopia where Schistosoma mansoni and Schistosoma hematobium are widespread. praziquantel has been the most effective drug and used as mass chemotherapy. However, recently low cure rate recorded in different parts of the word. As it is the only drug used for schistosomiasis, there is a need to periodically evaluate the efficacy in different geographic settings. So this study evaluateed efficacy of Praziquantel against S.mansoni. Cross-sectional study was conducted in Fincha...