These data have been used to arrive at the various parameters like partial molar volumes and their corresponding transfer functions, side chain contributions, interaction coefficients, activation parameters and hydration numbers. These parameters have been used to rationalize the nature of interactions amongst various amino acids/diglycine (solutes) and water (solvent) in the presence of various electrolytes. From the comparison of partial molar volumes of studied amino acids in aqueous solutions of sodium nitrate[Soto et al. (1999)], NaCl[Bhat et al. (1985)], sodium sulphate[Wadi and...

The interactions of water with the various functional groups of proteins play crucial role in determining the conformational stability of proteins. The interactions between charged biomolecules and ions can highly influence the behavior and conformation of former molecules in aqueous solutions and study of these interactions do provide an insight into their conformational stability and unfolding behavior. As the amino acids in vivo are not involved in pure aqueous medium, their studies in the presence of various electrolytes, non-electrolytes, zwitterions i.e. molecules of various sizes,...

It was observed that the chronic dose of lead caused an elevation in the level of proteins, acid phosphatase, alkaline phosphatase, alanine aminotransferase and aspartate aminotransferase in all the soft tissues studied indicating tissue damage, whereas it was observed be me (Dhir) the effects were more severe in case of cadmium. However no literature was available so far as to compare the toxicity level of cadmium with lead (because the cadmium ions or compounds are available in trace amount but I (Dhir) cannot rule out the possibility of cadmium pollution). Therefore it is necessary to...

The amino acids composition of protein determines their unique structure, function and folding kinetics. Proteins form an essential part of all living organisms and participate in every process within cells. Therefore understanding of the various types of interactions operating in between amino acids to protein folding is an extremely serious task that has been achieved by number of theoretical and experimental studies.Due to the complex conformational and configurational three-dimensional structures of protein direct investigations of the solute/solvent effect on these biological...