Diabetes is a progressive and life-threatening disease with potentially devastating consequences for health. The associated complications are retinopathy, nephropathy, and neuropathy, altered wound healing and periodontal disease. Conditions which exhibit altered tryptophan metabolism are patients undergoing orthodontic treatment, patients with oral squamous cell carcinoma, renal failure, hypertension or diabetes and periodontal disease. The role of metabolites of tryptophan via kynurenine pathway has been speculated in type 2 diabetes due to its anti-insulin action. In this study the...