The utility of nitrones in synthetic organic chemistry has been widely illustrated. The nitrone moiety can be regarded as a 3 centered dipolar 4 system, which enables 1,3-dipolar cycloaddition reactions with different dipolarophilic reagent to occur. 1,3-dipolar cycloaddition reaction between a nitrone and an olefinic dipolarophiles is an efficient method for the synthesis of isoxazolidine and isoxazoline ring systems. Nitrones are also versatile intermediates for the synthesis of natural products and many biologically interesting molecules. Owing to the labile nature of the N O bond under...