Direct compression method in tableting is widely used due to fewer processing steps, simplified validation, elimination of heat and moisture, economy and improved drug stability. Hence, the current trend in the pharmaceutical industry is to adopt direct compression technology. Most of the drugs do not possess direct compression characteristic. Hence, development of various functionality added excipients (FAEs) to achieve formulations with desired effects is equally important. Excipients with improved functionality can be obtained by developing new chemical excipients, new grades of existing...

The present invention is aimed to formulate the non-enteric formulation of immediate release rabeprazole sodium tablet using acid-buffer technology. The formulation comprising the core tablet containing rabeprazole sodium compression coated with buffer containing super disintegrant. The coat formulation disintegrates fast which provide the higher pH environment then the core formulation gives drug release so degradation of rabeprazole sodium can prevent. From the above perception, the invention is aimed: 1.To study the pH stability of rabeprazole sodium in at different pH medium. 2.To select...