Disease models such as the oncomouse and the Alzheimer s mouse have been hugely influential in the body of support for transgenic animals as they exhibit the most important of potential human benefits: aiding our understanding and treating life threatening illness. The use of animals for testing treatments is necessary because of the ethical gulf which prevents us from performing initial tests on humans. Biopharming represent another means of improving the human condition by producing human proteins in their milk, blood or eggs. The resultant protein can then be purified and used to treat...

Endosseous dental implants have revolutionized the fields of implants and periodontics. During the last decade, a great deal of information has been generatedconcerning the effectiveness and predictability of endosseous implants. Implant placement is a viable option in the treatment of partial and full edentulism and has become an integral facet of periodontal therapy. The available implants are remarkably successful. However, there is no one ideal implant system. The following areas need further study: edentulous sites with inadequate bone for endosseous implants, splinting of implants to...

Conventional drug delivery system were used for long time.Drug was usually administered in forms such as tablet, capsule, emulsion, suspension etc but administering drug using these conventional dosage form encountered a number of problems.The problems were mainly regarding poor distribution, stability, site delivery etc. most of these problems were solved by using Novel drug delivery system(NDDS). Liposome is one amongst those drug delivery system.With the help of liposomes it was possible to deliver the drug in a controlled manner. Drugs included in the liposomes directly reached to the...

BT cotton is a variety of cotton that genetically modified which contains a gene of Bacillus thuringiensis (BT), which is foreign to its genome. Different BT strains produce different Cry-proteins and there are hundreds of known strains. Major problem of today is that several insects developing resistance against BT cotton plant or there is no effect of BT toxic protein on insect control. In this context, this book addresses the problem using bioinformatics tools. Before developing BT cotton variety the most important thing is to check the binding efficiency of toxin protein to specific...

Any drug given in the form of parenteral dosage form like emulsion, suspension, solution etc. it is not best suited for the long time therapy. Long time drug release profile in controlled manner achieved by nano particle which is difficult by parenteral suspension or parenteral solution. Nano particulate drug delivery is the novel concept now a days. Nano particulate drug delivery is used to get maximum bio-availability for the potent drug with minimal side effect. Nano particulate drug delivery is also useful for maintaining the drug concentration in therapeutic window for the drug having...

Cancer is a second leading cause of death in the world. It has been a lot of research being done on cancer therapeutics but the deadliness of this disease has not been cured. This book insights into development of new avenue of synthetic compounds and their assessment in terms of effectiveness against major kinds of cancers i.e. lymphoma, breast cancer, and layrnx cancer along with safety study on kidney cells in vitro. In addition, it also describes number of assays available for screening. This can be useful to the students working on cancer research in chemistry, biochemistry as well as in...

Cancer Therapeutics is in new arena of developmental phase due to high impact cancer vaccines. Cancer Vaccines has been a buzz word due to good results in clinical trials. Some of the viral vaccines for treatment of HPV induced cancer are already present in market and are being recommended by different regulatory agencies worldwide. Current scenario of death toll due to cancer requires some miraculous therapy options and personalized cancer vaccine has shown promising results to be the one. This book takes insight in the latest development of cancer vaccines and can be useful to the...

Use of Herbal Compounds in cancer therapy is a much classic subject studied so far. Herbal drugs are being utilized for cancer treatment in various regions of the world since post civilization era. Nevertheless,Use of isolated herbal compounds has grown in much later phase. The natural flora has got amazing bunch of diversified and exquisite treasure of remedies. This book aims to usher light on the path of research that has been done so far including work that is being done today with herbal compounds to anyhow get rid of this deadly disease. Hopefully, this book will help students,...

Glycogen Synthase Kinase is a very large family of metabolically and physiologically important bio catalysts. Specifically, GSK 3 are of prime importance in case of its role in treatment of various diseases as well as other biological reactions. GSK3 is unusual in that its protein kinase activity is high in resting cells. Cellular stimulation through plethora of signaling pathways typically results in rapid and reversible reduction in its catalytic activity. Genetic analysis and use of selective inhibitors have shown that GSK3 plays a critical role in development, metabolic homeostasis,...

It was first described by Alois Alzheimer in 1906. At a scientific meeting in November 1906, German physician Alois Alzheimer presented the case of Frau Auguste D., a 51-year-old woman brought to see him in 1901 by her family. Auguste had developed problems with memory, unfounded suspicions that her husband was unfaithful, and difficulty speaking and understanding what was said to her. Her symptoms rapidly grew worse, and within a few years she was bedridden. She died in spring 1906.Dr. Alzheimer had never before seen anyone like Auguste D., and he gained the family s permission to perform an...