This thesis develops the dispersive optical model into a tool that allows for the assessment of the validity of nuclear reaction models, thereby generating unambiguous removal probabilities of nucleons from valence orbits using the electron-induced proton knockout reaction. These removal probabilities document the substantial quantitative degree in which nuclei deviate from the independent-particle model description. Another outcome reported within is the prediction for the neutron distribution of Ca-40, Ca-48, and Pb-208. The neutron radii of these nuclei have direct relevance for the...