The present study was designed to demonstrate the effect of monosodium glutamate on PRL level in prepubertal rabbits. Glutamate is a major neurotransmitter that acts on extensive brain regions, such as hypothalamus and the pituitary and induce the secretion of PRL. In this study, young male rabbits (Lates calcarifer) of 3 to 4 months of age were treated with 2mg/g body weight MSG dissolved in 0.9% saline. The animals in control group received equal quantity of 0.9% saline. Blood samples were collected 15 minutes after administration of drug, and plasma was separated. All plasma samples were...

Cortisol is the principal active glucocorticoid produced by the human adrenal gland, which is the key regulator of whole-body homeostasis. Cortisol is essential for provision of nutrients to tissues via carbohydrate, protein, and lipid metabolism. It also affects all of the major systems of the body, including the cardiovascular, musculoskeletal, nervous, and immune systems, and play critical roles in fetal development. Secretion of cortisol is controlled by hypothalamus, pituitary and the adrenal gland. CRH released from the hypothalamus acts on pituitary gland to release ACTH, which acts on...