The primary cilium is an important sensory organelle present in most mammalian cells. By virtue of its structure and location, the cilium acts as a sensor. It senses conditions in the extra cellular matrix and transduces these messages to cell interior, resulting in altered gene expression and protein synthesis. Dysfunctional cilia result in a variety of diseases, collectively known as ciliopathies. Our current studies have a two-fold aim. First, we show cilia length and functions are regulated by distinct, yet complex intertwined signaling pathways. Second, we show that dysfunctional...