This thesis makes significant advances in the quantitative understanding of two intrinsically linked yet technically very different phenomena in quantum chromodynamics (QCD).  Firstly, the thesis investigates the soft probe of strong interaction topological fluctuations in the quark-gluon plasma (QGP) which is made possible via the anomalous chiral transport effects induced by such fluctuations. Here, the author makes contributions towards establishing the first comprehensive tool for quantitative prediction of the chiral magnetic effect in the QGP that is produced in heavy ion...