This book provides a history of the foundational concepts of immunology and recognizes the central role of paradoxes, and their resolution, in advancing the canon. It identifies many paradoxes in the context of the contemporary, dominant frameworks employed by researchers in the last few decades to analyse how immune responses are regulated. The foundational ideas proposed resolve these paradoxes. The resulting framework emerges as a powerful platform for elucidating common immune mechanisms and proposing strategies to prevent and treat autoimmunity, cancer and certain problematical...