Hepatitis E virus (HEV) is significant international public health problem and is estimated that 2.3 billion people are infected globally. Blood-borne transmission of HEV had been investigated as indirect evidence implicating HEV as a potential transfusion risk by many investigators worldwide. The high prevalence rate of anti-HEV among blood donors, this will raise the potential risk of HEV infection by blood transfusion so that screening of HEV among blood donors before transfusion is very important.