Systemic diseases, such as cancer, require thorough understanding not only of the properties that malignant cells have acquired through mutations but also the effects of the activity of these cells on the dynamic microenvironment of the hosts tissue. From this perspective, one can think of tumor cells as being hosted by tumor endothelial cells within the larger "ecosystem" of the human body. And just like in other ecosystems, the survival of tumor cells depends both on the state of the entire ecosystem and on the state of their immediate host. The focus of this research lies in using...