The release of so called anti-diabetic, anti-obesity gut hormone cholecystokinin (CCK) from I-cells of the small intestine is stimulated by some food peptides, which in turn suppresses appetite by producing a feeling of satiety. This study investigated appetite-suppressive and CCK-releasing activity in peptides derived from proteins after enzymatic hydrolysis. The stimulatory activity was examined in a murine enteroendocrine cell (EEC) line STC-1 followed by investigating active peptides for appetite-suppression in rats. Among peptones prepared from meat and legumes, pork peptides suppressed...