The death of macrophages is important in the development of atherosclerosis, leading to the growth of the lipid core of the plaque. Cell death is due principally to the toxicity of oxidised LDL. However, cells may have a protective mechanism in the production of antioxidant 7,8-dihydroneopterin (78NP). THP-1 and U937 monocytes and macrophages were incubated with AAPH or oxidised LDL and loss of cell viability, total reduced thiols and cell death characteristics measured. Upon addition of 78NP, viability loss was decreased in the U937 cells only. The protective effect of 78NP may be dependent...
The death of macrophages is important in the development of atherosclerosis, leading to the growth of the lipid core of the plaque. Cell death is due ...
