The metabolism of iron is important considering the vital role of this element in proliferation. However, excess iron is toxic due to the generation of cytotoxic radicals. This book examines the targeting of iron by specific iron chelating agents in two disease states, namely cancer and Friedreich's ataxia. The research herein first results in the identification of a new class of iron chelators known as the DpT analogues that selectively inhibit tumour growth in a variety of human tumour models in vivo. At least part of their mechanism of action is mediated through their ability to...