The aim of this study Budesonide and Salmeterol xinafoate is latest combination of anti asthmatic drugs. It is available in dry powder inhalation and metered dose inhalation form. Present work describes simple, rapid, accurate and precise method for simultaneous determination of Budesonide and Salmeterol xinafoate in metered dose inhalation. The proposed methods were validated as per ICH guidelines.The method presents a reversed phase and stability-indicating method for analysis of Salmeterol Xinafoate and Budesonide drugs in metered dose inhalation.