Breast cancer, liver cancer (hepatocellular carcinoma, intrahepatic cholengiocarcinoma, gallbladder cancer), and lung cancers all are multi-genic diseases. As not all the genetic changes in the genomic data causes a disease to occur, but there are a very few number of variations in the codons of specific genes which cause any lethal effect. Thus, with the objective of statistical evaluation of significance of nucleotide positions in codons through SNPs in gene sequences implicated in cancers, and statistical analysis of codon expression level, reported genes for mentioned cancers were...