In 1949, the Dutch anatomist Jan Boeke was able to write: "The socalled interstitial cells ...which lie at the end of the sympathetic endformation as a connecting link between the nervous endformation and the effector cells, are ...shown to be of pri- mary importance for the transferring and the remoulding of the nervous stimulus ..." And: " ...the problem of the interstitial cells and of the synapse is the most impor- tant problem of neurohistology of the future. " When Boeke wrote this, he advocated the generalized concept, holding that inter- stitial cells were intercalated between...