This extensively revised textbook describes and defines the US healthcare delivery system, its many systemic challenges and the prior efforts to develop and deploy informatics tools to help overcome these problems. Now that electronic health record systems are widely deployed, the HL7 Fast Healthcare Interoperability standard is being rapidly accepted as the means to access and share the data stored in those systems and analytics is increasing being used to gain new knowledge from that aggregated clinical data, this book goes on to discuss health informatics from an historical...