The aim of present research work was to investigate a microparticles base hydrogel of Atenolol and Propranolol drugs. This study was designed to evaluated the effects of different formulations variables like drug: polymer ratio, drug: Poly Vinyl alcohol (PVA) ratio on various parameters like IQCS & Kurtosis Analysis which includes arithmetic mean diameter, surface length of mean diameter, volume surface mean diameter, weight moment mean diameter, surface number mean diameter, angle of repose, tap density, bulk density, swelling index, In vitro drug release studies, FTIR analysis, differential...

Metoprolol tartrate, a nonselective beta adrenergic blocking agent, is widely used in the treatment of hypertension, angina pectoris and many other cardiovascular disorders. The bioavailability of Metoprolol tartrate is low. Metoprolol tartrate is highly water soluble drug with relatively short biological half-life of 4-5 hrs and usual dose is 25 mg thrice daily. This demands high frequency of administration resulting in oscillation of plasma drug concentration, it is necessary to develop sustained release dosage form with extended clinical effect.Metoprolol Tartrate was formulated as...