Traditionally, drugs were discovered by testing compounds synthesized in time consuming multi-step processes against a battery of in vivo biological screens. Promising compounds were then further studied in development, where their pharmaceutical properties, metabolism and potential toxicity were investigated. Here we present a study on herbal lead compounds and their potential binding affinity to the effectors molecules of major diseases like endometrial cancer. Clinical studies demonstrate a positive correlation between the extent of PDK1 and malignant progression of pre cancerous lesions...