From the present results and previous studies, itcould be concluded that the neurotoxicity whichcaused by different cement components may be, inpart, due to the elevation in glutamate which lead toincrease the intracellular of calcium concentrationand the inhibition of membrane-bound Na+, K+, Ca2+ATPase activity which lead to cellular alterationsand death. So long term exposure to cement componentsas environmental pollutants may lead toneurodegenerative diseases.