The present work by Salman highlights the role of the renal sympathetic nerves in the regulation of kidney functions and determines how the normal regulatory systems are disturbed during the pathology of renal failure and diabetes. Using animal models of these diseases, the mediated reductions in renal hemodynamic and excretory functions were characterized and evaluated prior to and directly after the induction of acute renal denervation. Data from this research provided experimental evidence that augmented renal sympathetic nerve activity is an early consequence of some pathological states...