Sepsis is a systemic inflammatory response syndrome caused by infection. A range of biomarkers have been shown to correlate with disease activity and death in sepsis. However, targeting single downstream mediators in clinical sepsis trials, like the central proinflammatory cytokine TNF-, have been disappointing. A better approach may be inhibition of upstream inducers instead of downstream mediators of inflammation. The aims of this study were to find effective inhibitors of complement and CD14/TLR4/MD2, two key upstream innate immunity inducers of inflammation The studies were conducted in...