Anyone who has ever interpreted a cross-sectional image of the human brain knows that the wrinkles associated with old age run deeper than the skin. Indeed, widening of the grooves (sulci) within the cerebral cortex, along with enlargement of the fluid-containing spaces (ventricles) deep within the brain, are ubiquitous findings of age-related brain volume decline in neuroradiology. Yet, unlike old-age wrinkles, volume decline in the human brain may begin as early as age 5 and progresses steadily across the life-span, with dramatic acceleration in cases of neurodegenerative diseases, such as...
Anyone who has ever interpreted a cross-sectional image of the human brain knows that the wrinkles associated with old age run deeper than the skin. I...