Glioblastoma multiforme (GBM) is the most common and aggressive primary brain tumor in adults and confers a dismal prognosis. Despite intense effort, treatment remains a significant therapeutic challenge and new modalities are desperately needed. In recent years a population of cancer cells with neural stem cell (NSC)-like properties has been reported in GBM. It is hypothesized that these so- called brain cancer stem-like cells (bCSC) are involved in brain tumor initiation, progression and treatment resistance. The Notch signaling pathway is known to be important in maintaining an...