It is shown that dried plums are highly effective in preventing and reversing ovarian hormone deficiency-associated bone loss in a rat model of osteoporosis. Moreover, it is shown that dried plum supplementation significantly increases indices of bone formation in postmenopausal women. The bone protective effect of dried plum, in part, may be due to its polyphenol content. The intent of this study is to investigate the bone formation mechanisms of action of polyphenol extracted from dried plum using a cell culture system. Overall, the finding of the present study suggests that dried plum...