The use of allograft bone and other bone substitutes in orthopedic surgery has increased tremendously over the last few years. There are inherent problems with allograft tissues, however, such as the risk of disease transmission and immunologic incompatibility. Strategies to reduce these risks include improving allograft sterilization methods and developing bone tissue substitutes were evaluated in this book. Tissue engineering offers a potential avenue to overcome the limitations related to traditional bone substitutes. To enhance the bodys own repair system, i.e., tissue regeneration,...