The findings outlined in this thesis show
that VN:IGFBP:IGF-I complexes can elicit enhanced growth and
migration in cells derived from skin from both normal and
diabetic patients. Further, these responses are maintained
in conditions found in the diabetic wound microenvironment,
namely in the presence of high glucose and high calcium.
Together these findings demonstrate the potential of the
VN:IGFBP:IGF complexes as wound healing agents to treat
wounds, especially diabetic ulcers. Such delayed...