The epidemiological association between migraine and mood disorders has been reported since mid-twentieth century. This monograph describes one of the first studies into migraine's association with bipolar disorder. Unlike other studies, this one looks beyond the superficial and attempts to understand the biological basis of the bipolar disorder, migraine co- morbidity. To achieve this aim, the role of central serotonergic system was investigated by carrying out neuropharmacological challenge studies in patients with bipolar disorder or migraine alone, in those who had both, and in healthy...

In this book you will find new approaches regarding skin care in which a most widely used green tea is explored for skin care. Green tea is used as beverage by millions of people but a little is know about its topical applications. Here in this book you will read about non-invasive bioengineering techniques and how green tea is benificial when applied topicaly to the skin. Every aspect in this book is elaborated scientifically.

The present study was undertaken to develop oral sustained release tablets of metoprolol tartrate using natural hydrophilic matrix formers (xanthan gum and tragacanth). Sustained release matrix tablets of metoprolol tartrate were prepared by using different ratios of drug, xanthan gum and tragacanth. Microcrystalline cellulose (MCC) was used as diluent. The polymer was incorporated into a matrix system using direct compression technique. Different formulations were evaluated with respect to dissolution profile in 900 mL phosphate buffer (pH 6.8), 0.1 M HCl solution and distilled water for 12...