This SpringerBrief is a computational study of significant concerns and their role in forming long-term relationships between intelligent entities. Significant concerns include attitudes, preferences, affinities, and values that are held to be highly valued and meaningful: The means through which a person may find deeply held identity, purpose, and transformation. Significant concerns always engage the emotions and senses in a way that simply holding an opinion may or may not. For example, experiencing a significant concern may provoke deep feelings of awe and wonder in a way that deciding...