Since the mid-1990s, a revolution in regards to prescribing antipsychotics has taken place. Once utilized only for schizophrenia, the newer, second generation antipsychotics have now been approved for the treatment of bipolar disorders, depressive disorders, and autism spectrum disorders. They are often utilised elsewhere for the treatment of anxiety disorders, sleep disorders, and to calm agitated patients when dangerous behaviours occur. This book was developed with input of international authors of varying backgrounds to review the history and development of these agents.