The brain is often thought of as an immune-privilege site, implying that trafficking of immune cells and molecules into the central nervous system is limited or controlled so as to prevent collateral damage. Nevertheless, there is increasing evidence demonstrating complex interactions between the immune system and the nervous systems. The increasing evidence for the role of autoimmunity to neuronal proteins in both peripheral and central nervous system disorders has led to the development of animal models and in vitro systems to probe human disorders. This book reviews evidence for...