This open access book presents a comprehensive survey of modern operator techniques for boundary value problems and spectral theory, employing abstract boundary mappings and Weyl functions. It includes self-contained treatments of the extension theory of symmetric operators and relations, spectral characterizations of selfadjoint operators in terms of the analytic properties of Weyl functions, form methods for semibounded operators, and functional analytic models for reproducing kernel Hilbert spaces. Further, it illustrates these abstract methods for various applications, including...