Time delayed (lagged) variables are an inherent feature of biological/physiological systems.  For example, infection from a disease may at first be asymptomatic, and only after a delay is the infection apparent so that treatment can begin.Thus, to adequately describe physiological systems, time delays are frequently required and must be included in the equations of mathematical models.

The intent of this book is to present a methodology for the formulation and computer implementation of mathematical models based on time delay ordinary differential equations...