Lysosomal Pathways of Protein Degradation looks at cell biology from the view of a lysosome. It summarizes the composition and assembly of lysosomes in mammalian and yeast cells. It also reviews current knowledge about pathways of endocytosis and secretion and how both endocytosed and secreted proteins can be delivered to lysosomes for degradation. In addition, both vesicular and nonvesicular pathways are described for the uptake of cytoplasm and cytosolic proteins by lysosomes. Such pathways include macroautophagy, microautophagy and a direct protein import pathway. Each section contains...