This issue of the Medical Clinics of North America, devoted to Oral Medicine, is edited by Drs. Eric T. Stoopler and Thomas P. Sollecito. Articles in this issue include: Anatomical and examination considerations of the oral cavity; Common dental and periodontal diseases; Common dental and orofacial trauma; Normal variations of oral anatomy and common oral soft tissue lesions; Oral cancer; Oral mucosal disorders; Temporomandibular disorders (TMDs); Orofacial pain syndromes; and Salivary gland disorders.