Direct methods are now used in a variety of cases: X-ray, neutron or electron data; single crystal and powder data; small molecules and macromolecules. While direct methods solved in practice the phase problem for small molecules, their application to macromolecules is recent and still undergoing development. This book describes the fundamental methods; in particular it is shown how the methods can be optimized for powder, neutron or electron data, and how they can be integrated with isomorphous replacement, molecular replacement and anomalous dispersion techniques. Maximum entropy methods...
Direct methods are now used in a variety of cases: X-ray, neutron or electron data; single crystal and powder data; small molecules and macromolecules...
