This volume contains the proceedings of an NSF-CBMS Conference held at Texas Christian University in Fort Worth, Texas, May 18-22, 2009. The papers, written especially for this volume by well-known mathematicians and mathematical physicists, are an outgrowth of the talks presented at the conference. Topics examined are highly interdisciplinary and include, among many other things, recent results on D-brane charges in $K$-homology and twisted $K$-homology, Yang-Mills gauge theory and connections with non-commutative geometry, Landau-Ginzburg models, $C^*$-algebraic non-commutative geometry and...