This book constitutes the refereed proceedings of the 4th International Conference on Advances in Quantitative Ethnography, ICQE 2022, held in Copenhagen, Denmark, during October 15–19, 2022.The 29 full papers included in this book were carefully reviewed and selected from 71 submissions. They were organized in topical sections as follows: QE Theory and Methodology Research;  Applications in Education Contexts; and Applications in Interdisciplinary Contexts.