This book contains the Proceedings of the Ninth Meeting on CPT and Lorentz Symmetry, held at Indiana University in Bloomington May 17-26, 2022. The Meeting focused on tests of these fundamental symmetries and on related theoretical issues, including scenarios for possible violations. Experimental topics covered at the meeting include astrophysical observations of neutrinos, photons, cosmic rays, pulsars, and gravitational waves; investigations at accelerators and storage rings involving neutral mesons, muons, quarks, and flavor-changing processes; gravity tests in the laboratory and in the...