​This book constitutes the refereed proceedings of the 5th IEEE Colombian Conference on Applications of Computational Intelligence, ColCACI 2022, held in Cali, Colombia during July 27–29, 2022.The 7 extended papers included in this book were carefully reviewed and selected from 38 submissions. They were organized in topical sections as follows: ​Design of a segmentation and classification system for seed detection based on pixel intensity thresholds and convolutional neural networks.