This proceedings, ICAST 2022, constitutes the refereed post-conference proceedings of the 10th International Conference on Advancement of Science and Technology, ICAST 2022, which took place in Bahir Dar, Ethiopia, in November 2022.The 17 revised full papers and one short paper were carefully reviewed and selected from 174 submissions. The papers present economic and technologic developments in modern societies related to important issues such digitization, energy transformation, impact on national economy, and its recent advancements.