This book constitutes the refereed proceedings of the 35th Australasian Joint Conference on Artificial Intelligence, AI 2022, which took place in Perth, WA, Australia, in December 5–8, 2022.The 56 full papers included in this book were carefully reviewed and selected from 90 submissions. They were organized in topical sections as follows: Computer Vision; Deep Learning; Ethical/Explainable AI; Genetic Algorithms; Knowledge Representation and NLP; Machine Learning; Medical AI; Optimization; and Reinforcement Learning.