This book constitutes the proceedings of the 18thInternational Symposium on Applied Reconfigurable Computing, ARC 2022, held as a virtual event, in September 2022.The 13 full papers presented in this volume were reviewed and selected from 16 submissions. The papers cover a broad spectrum of applications of reconfigurable computing, from driving assistance, data and graph processing acceleration, computer security to the societal relevant topic of supporting early diagnosis of Covid infectious conditions.