This book constitutes the refereed proceedings of the 23rd International Conference on Principles and Practice of Multi-Agent Systems, PRIMA 2020, held  in hybrid mode in Valencia, Spain, in November 2022. The 31 full papers presented together with 15 short papers and 1 demo paper were carefully reviewed and selected from 100 submissions.The conference covers a wide range of ranging from foundations of agent theory and engineering aspects of agent systems, to emerging interdisciplinary areas of agent-based research.